Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study
Cardiovascular epidemiology
Comments
3 open comments
DH
Dr. Helen CarterChange request · May 22, 2026, 9:06 AM
Please keep the approval summary specific: early-adult DBP and LDL remained independently associated after adjustment; SBP and HDL did not.
Abstract results
DM
Dr. Michael AbramsResolved · May 22, 2026, 10:14 AM
Citation and license look acceptable. Please keep the PLOS DOI, CC BY attribution, and BioLINCC data-availability context in the export record.
Citation and license
DE
Dr. Elaine RossChange request · May 22, 2026, 10:32 AM
The methods note should explain that young-adult exposure was estimated from mixed-model trajectories, not directly observed for every participant at ages 20-39.
Trajectory modeling methods
DJ
Dr. Jonah LeeComment · May 22, 2026, 11:08 AM
Table 3 is the right place to anchor the adjusted hazard-ratio discussion: DBP >90 and LDL >160 have the strongest adjusted estimates.
Please keep the approval summary specific: early-adult DBP and LDL remained independently associated after adjustment; SBP and HDL did not.
Abstract resultsCitation and license look acceptable. Please keep the PLOS DOI, CC BY attribution, and BioLINCC data-availability context in the export record.
Citation and licenseThe methods note should explain that young-adult exposure was estimated from mixed-model trajectories, not directly observed for every participant at ages 20-39.
Trajectory modeling methodsTable 3 is the right place to anchor the adjusted hazard-ratio discussion: DBP >90 and LDL >160 have the strongest adjusted estimates.
Table 3