Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

Cardiovascular epidemiology

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3 open comments

Dr. Helen CarterChange request · May 22, 2026, 9:06 AM

Please keep the approval summary specific: early-adult DBP and LDL remained independently associated after adjustment; SBP and HDL did not.

Abstract results

Dr. Michael AbramsResolved · May 22, 2026, 10:14 AM

Citation and license look acceptable. Please keep the PLOS DOI, CC BY attribution, and BioLINCC data-availability context in the export record.

Citation and license

Dr. Elaine RossChange request · May 22, 2026, 10:32 AM

The methods note should explain that young-adult exposure was estimated from mixed-model trajectories, not directly observed for every participant at ages 20-39.

Trajectory modeling methods

Dr. Jonah LeeComment · May 22, 2026, 11:08 AM

Table 3 is the right place to anchor the adjusted hazard-ratio discussion: DBP >90 and LDL >160 have the strongest adjusted estimates.

Table 3

Young Adult Exposure to Cardiovascular Risk Factors and Risk of Events Later in Life: The Framingham Offspring Study

pletcher-framingham-offspring-study-2016.pdf